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Horm Metab Res 1969; 1(3): 108-110
DOI: 10.1055/s-0028-1095159
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© Georg Thieme Verlag KG Stuttgart · New York

Evidence for the Presence of A-Cells in the Endocrine Fetal Pancreas of the Rat

L.  Orci , A. E. Lambert , Ch.  Rouiller , A. E. Renold , E.  Samols
  • Institut d'Histologie et d'Embryologie, and Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland and Medical College of Georgia, Augusta, Georgia, USA
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

With the electron microscope, typical endocrine pancreatic A-cells have been identified in fetal rat pancreas from 18 days of gestation to birth. Earlier gestational stages have not been studied. The A-cells were seen both in tissue fixed immediately and in tissue maintained under organ culture conditions for one or more days. A-cells were less numerous than B-cells in all instances. These morphological observations were confirmed by the detection of measurable glucagon-like immunoreactivity in fetal rat pancreas obtained at the same stages of gestation.

Key words

Pancreatic A-Cells - Fetal Rat Pancreas - Immunoreactive Glucagon Content