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Horm Metab Res 1972; 4(4): 280-283
DOI: 10.1055/s-0028-1094067
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© Georg Thieme Verlag KG Stuttgart · New York

Adrenocortical Responsiveness to Physiological Amounts of β1-24 ACTH

II. Effect of Acute Corticotrophin Treatment in Patients Receiving Prolonged Glucocorticoid TherapyR.  Leclercq , G.  Copinschi , O. D. Bruno
  • Laboratories of Clinical Chemistry, Experimental Medicine and Physiopathology, and Department of Internal Medicine, Hôpital Saint Pierre, Université Libre de Bruxelles, Bruxelles, Belgium
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Adrenocortical responsiveness was assessed in ten asthmatic patients treated with corticosteroids for at least one year. After an acute treatment with tetracosactrin (0.25 mg every six hours for two days), both the adrenocortical responses to physiological-like amounts of β1-24ACTH and the capacity of maximal response were significantly increased. However, the adrenocortical sensitivity remained altered.

Key words

Adrenocortical Sensitivity - Plasma Cortisol - Tetracosactrin - Acute ACTH Treatment - Long-Term Glucocorticoid Treatment.