Asymmetric Hydrogen-Transfer Reaction with Polymer-Supported
Ru Catalysts

Y. Arakawa; A. Chiba; N. Haraguchi; S. Itsuno

doi:10.1055/s-0028-1087249

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Synfacts 2009(1): 0105-0105
DOI: 10.1055/s-0028-1087249

Polymer-Supported Synthesis

Asymmetric Hydrogen-Transfer Reaction with Polymer-Supported Ru Catalysts

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
Y. Arakawa, A. Chiba, N. Haraguchi, S. Itsuno*
Toyohashi University of Technology, Japan

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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The polymer-supported chiral 1,2-diamine monosulfonamides 4 and 5 were prepared by reaction of 1, 2, and 3 with AIBN in DMF. The asymmetric hydrogen-transfer reaction of ketones with the polymer-supported ligand (1.2 mol% of 4 or 5), [RuCl₂(p-cymene)]₂ (0.5 mol% of Ru) and HCO₂Na in water gave the corresponding alcohols in 46-100% conversion and 60-99% ee values.