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Horm Metab Res
DOI: 10.1055/a-2276-7973
Review

Cross-Talk Between Thyroid Disorders and Nonalcoholic Fatty Liver Disease: From Pathophysiology to Therapeutics

Yan Yang
1   Department of Endocrinology and Metabolism, Lanzhou University Second Hospital, Lanzhou, China
,
Jiyuan Xiao
2   Department of Pharmacology, Lanzhou University Second Hospital, Lanzhou, China
,
Wen Qiu
2   Department of Pharmacology, Lanzhou University Second Hospital, Lanzhou, China
,
Luxia Jiang
3   Department of Cardiac Surgery ICU, Lanzhou University Second Hospital, Lanzhou, China
› Author Affiliations Funding Information Health Industry Scientific Research Project of Gansu Province — GSWSKY2018–35 “Cuiying Science and Technology Innovation” program of Lanzhou University Second Hospital — CY2018-MS01 National Natural Science Foundation of China — http://dx.doi.org/10.13039/501100001809; 81960165
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Abstract

The medical community acknowledges the presence of thyroid disorders and nonalcoholic fatty liver disease (NAFLD). Nevertheless, the interconnection between these two circumstances is complex. Thyroid hormones (THs), including triiodothyronine (T3) and thyroxine (T4), and thyroid-stimulating hormone (TSH), are essential for maintaining metabolic balance and controlling the metabolism of lipids and carbohydrates. The therapeutic potential of THs, especially those that target the TRβ receptor isoform, is generating increasing interest. The review explores the pathophysiology of these disorders, specifically examining the impact of THs on the metabolism of lipids in the liver. The purpose of this review is to offer a thorough analysis of the correlation between thyroid disorders and NAFLD, as well as suggest potential therapeutic approaches for the future.

Keywords

thyroid disorders - NAFLD - pathophysiology - therapeutics


Publication History

Received: 16 December 2023

Accepted after revision: 26 February 2024

Accepted Manuscript online:
26 February 2024

Article published online:
05 April 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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