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Synfacts 2008(7): 0720-0720  
DOI: 10.1055/s-2008-1077841
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Cyclopropanation with Cobalt-Porphyrin Complex

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
S. Zhu, J. V. Ruppel, H. Lu, L. Wojtas, X. P. Zhang*
University of South Florida, Tampa, USA
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Publikationsdatum:
20. Juni 2008 (online)

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Significance

In previous work the authors have reported the asymmetric cyclopropanation of various olefin substrates with diazoacetates using several Co-porphyrin complexes. Additionally, others have utilized Cu, Rh, Ru systems to effect cyclopropanation while also making use of diazo­acetates as carbene sources. In the present study a cobalt-porphyrin complex is applied to catalyze the cyclopropanation of a variety of olefinic substrates in excellent yields and selectivites, employing diazosulfones as the carbene source.