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Synfacts 2008(1): 0076-0076  
DOI: 10.1055/s-2007-991446
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Aminocarbonylation of Aryl Halides

Contributor(s): Paul Knochel, Tobias Thaler
J. Ju, M. Jeong, J. Moon, H. M. Jung, S. Lee*
Chonnam National University, Gwangju and Korea Research Institute of Chemical Technology, Korea
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

This method represents the first synthetically convenient and economic nickel-catalyzed aminocarbonylation. DMF is directly coupled to the respective aryl bromides or iodides. Aryl halides with electron-donating substituents generally give high yields, while only low yields are received with electron-deficient substitution patterns.