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Synfacts 2006(8): 0848-0848
DOI: 10.1055/s-2006-942027
DOI: 10.1055/s-2006-942027
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
Bifunctional Catalyst for the Michael Addition of Cyclohexanone to Nitroolefins
C.-L. Cao, M.-C. Ye, X.-L. Sun, Y. Tang*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
21 July 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200608/lookinside/thumbnails/10.1055-s-2006-942027-1.jpg)
Significance
Here the authors report a pyrrolidine-thiourea bifunctional catalyst for the enantioselective Michael addition of cyclohexanone to nitroolefins. The authors have observed an improved reaction rate when using n-butyric acid as additive. With 20 mol% of the catalyst 1, good to excellent yields (63-99%) and excellent enantioselectivities (88-98%) are obtained for different aryl and alkyl nitroolefins.