Asymmetric Construction of Quaternary Carbon Stereocenters

Significance

The authors have found a fine protocol for the construction of all-carbon chiral quaternary stereocenters. They discovered that the use of the bidentate phosphine ligand (R)-H₈-BINAP provides opposite regioselectivity to the diene ligands (R,R)-Bn-bod and (R,R)-Ph-bod. High enantio­selectivities for the addition of a variety of arylboronic acids were obtained. The regioselectivity was as high as >98:2 (1:2) in some cases. Various electron-donating as well as electron-withdrawing groups on the aryl moiety of the arylboronicacids were tolerated.