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Synfacts 2006(8): 0755-0755  
DOI: 10.1055/s-2006-941932
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ecteinascidin 743

Contributor(s): Philip Kocienski
S. Zheng, C. Chan, T. Furuuchi, B. J. D. Wright, B. Zhou, J. Guo, S. J. Danishefsky*
Columbia University and Sloan-Kettering Institute for Cancer Research, New York, USA
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Publication History

Publication Date:
21 July 2006 (online)

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Significance

Ecteinascidin 743 is a potent antitumor agent. The Danishefsky group reports a synthesis of an advanced intermediate F featuring a vinylogous Pictet-Spengler reaction to create the C and D rings simultaneously. Intermediate F had been transformed to Ecteinascidin 743 by T. Fukuyama and co-workers (J. Am. Chem. Soc. 2002, 124, 6552-6554).