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Synfacts 2005(3): 0360-0360
DOI: 10.1055/s-2005-921609
DOI: 10.1055/s-2005-921609
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Polymer-Micelle Incarcerated (PMI) Scandium as a Polymer-Supported Catalyst
M. Takeuchi, R. Akiyama, S. Kobayashi*
University of Tokyo, Japan
Further Information
Publication History
Publication Date:
22 November 2005 (online)
Significance
The authors have reported an immobilization technique for Sc(OTf)3. The PMI Sc(OTf)3, which was prepared from copolymer 1 and Sc(OTf)3, showed high catalytic activity for Mannich-type, Mukaiyama aldol, and Michael reactions. For example, compound 2 was treated with 1.5 equivalents of silyl enolate 3 in the presence of 10 mol% of PMI Sc(OTf)3 to give compound 4 in 96% yield. This catalyst was recovered by simple filtration and was reused three times without any loss of reactivity (2nd: 99% yield, 3rd: 97% yield). In all reactions, no Sc leaching was observed (less than 0.1 ppm: ICP analysis).