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Synfacts 2005(3): 0350-0350  
DOI: 10.1055/s-2005-921604
Bioorganic Chemistry and Organocatalysis
© Georg Thieme Verlag Stuttgart · New York

Multidentate Hydrogen Donor Catalyzed Addition to Imines

Contributor(s): Benjamin List, Sebastian Hoffmann
D. J. Dixon*, A. L. Tillman
The University of Manchester, UK
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

A novel series of Binol-derived multidentate Brønsted acid catalysts is described. The catalysts were used for the addition reaction of methyleneaminopyrrolidine to N-Boc imines to afford the corresponding protected α-aminohydrazones in 44-87% yield and up to 75% ee (9 examples, 20 mol% catalyst, r.t.).