Download PDF
Planta Med 2001; 67(2): 179-181
DOI: 10.1055/s-2001-11513
Letter

© Georg Thieme Verlag Stuttgart · New York

Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract

Kazunori Hashimoto1,*, Kazuko Satoh1 , Yoshio Kase1 , Atsushi Ishige1 , Masayoshi Kubo1 , Hiroshi Sasaki1 , Shigeto Nishikawa2 , Susumu Kurosawa2 , Koji Yakabi2 , Takashi Nakamura2
  • 1 Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan
  • 2 The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan
Further Information

Publication History

March 23, 2000

July 16, 2000

Publication Date:
31 December 2001 (online)

    Permissions and Reprints

Abstract

β-Sanshool and γ-sanshool, unsaturated aliphatic acid amides isolated from the pericarpium of Zanthoxylum piperitum De Candolle (Rutaceae), relax the circular muscle of the gastric body, as well as contract the longitudinal muscle of the ileum and distal colon in an experimental system using the gastrointestinal tract isolated from a guinea pig.

References

  • 1 Horie Y, Kato K, Hamano K. An overview of our surgery-oriented Kampo.  Journal of Tokyo Women's Medical College. 1995;  65 43-51
    PubMedGoogle Scholar
  • 2 Kurosawa S, Nishikawa S, Kaneko M, Nakamura T. The herbal medicine Dai-Kenchu-to contract guinea pig colon muscle while relax the gastric muscle.  Gastroenterology. 1997;  112 A 768
    PubMedGoogle Scholar
  • 3 Kurosawa S, Nishikawa S, Kaneko M, Ogiwara S, Ro S, Nakamura T, Saito K, Hayakawa T, Kase Y, Ishige A. The herbal medicine Dai-Kenchu-to contract guinea pig distal colon muscle through acetylcholine release.  Gastroenterology. 1998;  114 A 782
    PubMedGoogle Scholar
  • 4 Kurosawa S, Nishikawa S, Kaneko M, Ogiwara S, Ro S, Nakamura T, Saito K, Hashimoto K, Kase Y, Ishige A. Hydroxy-β-sanshool extracted from the herbal medicine Dai-Kenchu-to contracts the ileal and colonic muscle as well as relaxes the gastric muscle in the guinea pig.  Gastroenterology. 1999;  116 A 1021
    PubMedGoogle Scholar
  • 5 Yasuda I, Takeya K, Itokawa H. Two new pungent principles isolated from the pericarps of Zanthoxylum ailanthoides .  Chemical Pharmaceutical Bulletin. 1981;  29 1791-3
    PubMedGoogle Scholar
  • 6 Yasuda I, Takeya K, Itokawa H. Distribution of unsaturated aliphatic acid amides in Japanese Zanthoxylum species.  Pyhtochemistry. 1982;  21 1295-8
    PubMedGoogle Scholar
  • 7 Yasuda I, Takeya K, Itokawa H. Evaluation of Chinese Zanthoxyli Fructus commercially available in Japan by pungent principles and essential oil constituents.  Shoyakugaku Zasshi. 1982;  36 301-6
    PubMedGoogle Scholar
  • 8 Saitoh K, Kase Y, Ishige A, Komatsu Y, Sasaki H, Shibahara N. Effects of Keishi-ka-shakuyaku-to on diarrhea and small intestinal movement.  Biological Pharmaceutical Bulletin. 1999;  22 87-9
    PubMedGoogle Scholar

Dr. Kazunori Hashimoto

Kampo & Pharmacognosy Laboratory

3586 Yoshiwara

Ami-machi

Inashiki-gun

Ibaraki 300-11

Japan

Email: hashimoto_kazunori@mail.tsumura.co.jp

Fax: +81-298-89-3832

      >