RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2009(5): 0552-0552
DOI: 10.1055/s-0028-1088186
DOI: 10.1055/s-0028-1088186
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Regioselective Hydration of Alkynoates: A Facile Synthesis of γ-Keto Esters
B. Xu, W. Wang, G. B. Hammond*
University of Louisville, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
The authors demonstrate here an efficient synthesis of γ-keto esters via an intramolecular reaction of alkynecarboxylic acid esters in the presence of catalytic amounts of sodium tetrachloroaurate(III) hydrate. The reaction proceeds at room temperature, is very atom-economical and applicable to a wide range of substrates. The products are generally obtained in good to very good yields.