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Horm Metab Res 2023; 55(03): 196-204
DOI: 10.1055/a-2020-2080
Original Article: Endocrine Care

The Associations of Dietary Vitamin K Intake and Circulating Vitamin 25(OH)D with Serum Lipoprotein Levels: The Vitamin Deficiency Matters

Nikolaos Varsamis
1   Atherothrombosis Research Centre, University of Ioannina Faculty of Medicine, Ioannina, Greece
,
Georgios A Christou
1   Atherothrombosis Research Centre, University of Ioannina Faculty of Medicine, Ioannina, Greece
,
Christos Derdemezis
1   Atherothrombosis Research Centre, University of Ioannina Faculty of Medicine, Ioannina, Greece
,
Alexandros Tselepis
2   Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece
,
Dimitrios Kiortsis
1   Atherothrombosis Research Centre, University of Ioannina Faculty of Medicine, Ioannina, Greece
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Abstract

A synergistic interplay between vitamins K and D appears to exist. We aimed to investigate for the first time whether the associations of dietary vitamin K intake and circulating 25(OH)D with serum lipoprotein levels are influenced by the existence of deficiency of either or both vitamins K and D. Sixty individuals [24 males, 36(18–79) years old] were examined. Vitamin deficiency of K1 and D were defined as vitamin K1 intake/body weight (BW)<1.00 μg/kg/day and circulating 25(OH)D<20 ng/ml, respectively. In individuals with vitamin K1 deficiency, the vitamin K1 intake/BW correlated positively with high density lipoprotein-cholesterol (HDL-C) (r=0.509, p=0.008) and negatively with serum triglycerides (TG) (r=–0.638, p=0.001), whereas circulating 25(OH)D correlated negatively with TG (r=–0.609, p=0.001). In individuals with vitamin D deficiency, the vitamin K1 intake/BW correlated positively with HDL-C (r=0.533, p=0.001) and negatively with TG (r=–0.421, p=0.009), while circulating 25(OH)D correlated negatively with TG (r=–0.458, p=0.004). The above-mentioned associations of vitamin K1 intake/BW and circulating 25(OH)D with serum lipoproteins were not detected in individuals without vitamin K1 deficiency or the ones without vitamin D deficiency. The vitamin K2 intake/BW correlated negatively with low density lipoprotein-cholesterol (LDL-C) (r=–0.404, p=0.001). In conclusion, the associations of vitamin K1 intake with TG and HDL-C and of circulating 25(OH)D with TG were more pronounced in individuals with deficiency of either or both vitamins K1 and D. Increased dietary vitamin K2 intake was associated with decreased LDL-C.

Key words

vitamin D  - vitamin K - lipoproteins


Publication History

Received: 31 October 2022

Accepted after revision: 21 December 2022

Article published online:
27 February 2023

© 2023. Thieme. All rights reserved.

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