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Synlett 2000; 2000(5): 0674-0676
DOI: 10.1055/s-2000-6628
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Copper Promoted Aryl/Saturated Heterocyclic C-N Bond Cross-Coupling with Arylboronic Acid and Arylstannane

Patrick Y. S. Lam* , Charles G. Clark, Simon Saubern, Jessica Adams, Kristin M. Averill, Dominic M. T. Chan, Andrew Combs
  • *DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA; Fax (302) 695-9673; E-mail: patrick.y.lam@dupontpharma.com
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Publication Date:
31 December 2000 (online)

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Arylboronic acid/cupric acetate arylation of N-H containing saturated heterocycles has been explored and found to give good yields of the cross-coupled products. Phenyltrimethylstannane is also found to arylate N-H containing heterocycles.

N-arylation - copper(II) acetate - stannane - boronic acid - cross-coupling