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Synlett 1999; 1999(5): 620-622
DOI: 10.1055/s-1999-2659
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6-Aryl-11H-indolo[3,2-c]quinolines through the Palladium-Catalyzed Carbonylative Cyclization of o-(o-Aminophenyl)trifluoroacetanilide with Aryl Iodides

Sandro Cacchi1 , Giancarlo Fabrizi, Paola Pace, Fabio Marinelli2
  • 1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy; Fax +39(6)49 91.27 80; E-mail: cacchi@uniroma1.it
  • 2Dipartimento di Chimica, Ing. Chimica e Materiali, Via Vetoio, 67100 L'Aquila, Italy; Fax +39(6)49 91.27 80
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Publikationsdatum:
31. Dezember 1999 (online)

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6-Aryl-11H-indolo[3,2-c]quinolines are prepared through a straightforward palladium-catalyzed carbonylative cyclization of o-(o'-aminophenylethynyl)trifluoroacetanilide with aryl iodides followed by the cyclization of the resultant 3-acylindole derivatives. The reaction is best carried out as a one-pot process.

indoloquinolines - cyclization - palladium catalysis - carbonylation - alkynes

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