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Synlett 1999; 1999(4): 483-485
DOI: 10.1055/s-1999-2646
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A Remarkable Improvement of Catalytic Performance by Electronic Substituent Effects of Chiral P-N Hybrid Ligands in Palladium-Mediated Asymmetric Allylations

Akihito Saitoh* , Mie Misawa, Toshiaki Morimoto
  • *School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan; Fax +8 15 42 64 57 40
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Publication Date:
31 December 1999 (online)

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A marked advancement of reactivity and enantioselectivity in palladium-catalyzed asymmetric allylations was achieved by variations of electronic substituent effects in a new series of chiral P-N hybrid ligands 1. The first evident observation demonstrates that the introduction of electron-donating groups is effective to improve the catalytic performance in the allylic transformation.

chiral P-N hydrid ligand - electronic substituent effect - electron-donating group - palladium catalyst - asymmetric allylation

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