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Synlett 1994; 1994(2): 137-140
DOI: 10.1055/s-1994-22769
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Antisense Oligonucleotides with Alternating Phosphodiester-"Amide-3" Linkages

Jacques Lebreton* , Adrian Waldner, Catherine Lesueur, Alain De Mesmaeker
  • *Central Research Laboratories, Ciba-Geigy Ltd., CH-4002 Basel, Switzerland
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Publication Date:
22 March 2002 (online)

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The synthesis of the building blocks required for the preparation of all the "amide-3" dimers is reported. Five representative dimers are described, as well as the melting temperatures (Tm) of the duplexes formed between an oligonucleotide containing alternating phosphodiester-"amide-3" linkages with its complementary DNA and RNA strand.

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