Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Abstract

The Vilsmeier–Haack reaction has historically been a topic of significant interest to organic chemists, and it continues to attract considerable attention. The reaction itself provides a facile route towards a large number of aromatic and heteroaromatic systems. The Vilsmeier–Haack reagent, generated from amides and halides, is found to be very important in organic synthesis. This account highlights recent developments in the synthetic utility of the Vilsmeier–Haack reagent.

1 Introduction

2 Formylation

3 Formylation and Chlorination

4 Formylation and Acetylation

5 Chlorination

6 ortho-Formylation

7 Miscellaneous

8 Conclusions

Key words

Vilsmeier–Haack reagent - formylation - chlorination - heterocycles

Publication History

Received: 18 September 2022

Accepted after revision: 18 January 2023

Article published online:
28 February 2023

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