TY - JOUR AU - Lambert, Michele P.; Sachais, Bruce S.; Kowalska, M. Anna TI - Chemokines and thrombogenicity SN - 0340-6245 SN - 2567-689X PY - 2007 JO - Thromb Haemost JF - Thrombosis and Haemostasis LA - EN VL - 97 IS - 05 SP - 722 EP - 729 DA - 2017/11/24 KW - Chemokines KW - thrombosis KW - atherosclerosis KW - chemokine receptors KW - platelets AB - Thrombosis is an important clinical entity, and pathologic thrombosis, in the form of atherosclerosis, is a major cause of morbidity and mortality. Recent research points to the role of chemokines, normally key factors in inflammation, in thrombogenesis. Many recent studies in murine transgenic and knockout models show that chemokines and their receptors are important modulators of the process of thrombus formation, particularly in atherosclerosis. Platelet-released chemokines can potentiate or inhibit thrombosis and inflammation.This review focuses on the role of chemokines in platelet activation and thrombosis, particularly as it relates to atherosclerosis. Further studies to define this complex interaction are underway. PB - Schattauer GmbH DO - 10.1160/TH07-01-0046 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1160/TH07-01-0046 ER -