SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. - Emanuelli,B.; Peraldi,P.; Filloux,C.; Chavey,C.; Freidinger,K.; Hilton,DJ.; Hotamisligil,GS.; Obberghen,E Van. (J Biol Chem, 2001)