The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. - Breedveld,F.C.; Weisman,M.H.; Kavanaugh,A.F. (Arthritis Rheum, 2006)