Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells. - Kempuraj,D.; Papadopoulou,NG.; Lytinas,M.; Huang,M.; Kandere-Grzybowska,K.; Madhappan,B.; Boucher,W.; Christodoulou,S.; Athanassiou,A.; Theoharides,TC. (Endocrinology, 2004)