Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat - Heuman,D.M.; Mills,A.S.; McCall,J.; Hylemon,P.B.; Pandak,W.M.; Vlahcevic,Z.R. (Gastroenterology, 1991)