Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. - Bucay,N.; Sarosi,I.; Dunstan,C.R.; Morony,S.; Tarpley,J.; Capparelli,C.; Scully,S.; Tan,H.L.; Xu,W.; Lacey,D.L.; Boyle,W.J.; Simonet,W.S. (Genes Dev, 1998)