Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance. - Dib,K.; Whitehead,J.P.; Humphreys,P.J.; Soos,M.A.; Baynes,K.C.; Kumar,S.; Harvey,T.; O’Rahilly,S. (J Clin Invest, 1998)