Homozygous alpha-thalassemia associated with hypospadias: SEA-type deletion does not affect expression of the -14 gene and loss of the theta1-globin gene on 16p13. 3 is compensated by its duplicate theta2 on chromosome 10. - Utsch,B.; Albers,N.; Dame,C.; Bartmann,P.; Lentze,M.J.; Ludwig,M. (Am J Med Genet, 2001)