Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. - Feugeas,O.; Guriec,N.; Babin-Boilletot,A.; Marcellin,L.; Simon,P.; Babin,S.; Thyss,A.; Hofman,P.; Terrier,P.; Kalifa,C.; Brunat-Mentigny,M.; Patricot,L.M.; et al. (J Clin Oncol, 1996)