The hsp90-binding antibiotic geldanamycin decreases raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of raf kinase. - Stancato,L.F.; Silverstein,A.M.; Owens-Grillo,J.K.; Chow,Y.H.; Jove,R.; Pratt,W.B. (J Biol Chem, 1997)