The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. - Grenert,J.P.; Sullivan,W.P.; Fadden,P.; Haystead,T.AJ.; Clark,J.; Mimnaugh,E.; Krutzsch,H.; Ochel,H.J.; Schulte,T.W.; Sausville,E.; Neckers,L.M.; Toft,D.O. (J Biol Chem, 1997)