TY - JOUR AU - Haghikia, Aiden; Linker, Ralf TI - Diet, Microbiome and Multiple Sclerosis SN - 2511-1795 PY - 2018 JF - Neurology International Open LA - EN VL - 02 IS - 01 SP - E40 EP - E43 DA - 2018/01/31 KW - microbiome KW - diet KW - MS KW - gut AB - During recent years, research into the causes of multiple sclerosis (MS), especially in the field of genetic risks of this disease, has made immense advances, thanks to new molecular biology techniques and large consortia. However, the functional relevance of disease-associated risk gene variants remains unclear, and representing about one-third of the overall risk compared to environmental risk factors, plays a smaller role. Thus, the further identification and, where appropriate, prevention of environmental risks is currently the focus of research. Here recently, risk factors for MS have been shown which are closely related to Western diet and lifestyle, such as high consumption of salt and cigarette smoking. In addition, the human gut continues to be the focus of research: with its large surface, the gut offers immense opportunities for interaction between intestinal bacteria, food and their metabolic products, as well as the immune system associated with the gut. In the present paper, we summarize the findings of the constantly growing research field dealing with the gut, nutrition and MS, and discuss how these findings, as shown recently for fatty acids, could have translational-therapeutic potential. PB - © Georg Thieme Verlag KG DO - 10.1055/s-0043-111782 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-111782 ER -