TY - JOUR AU - Spinelli, M.; Sica, C.; Meglio, L. D.; Bolla, D.; Raio, L.; Surbek, D. TI - Fetal Cerebellar Vermis Circumference Measured by 2-Dimensional Ultrasound Scan: Reference Range, Feasibility and Reproducibility SN - 2509-596X SN - 2199-7152 PY - 2016 JO - Ultrasound Int Open JF - Ultrasound International Open LA - EN VL - 02 IS - 04 SP - E124 EP - E128 DA - 2016/11/24 KW - prenatal diagnosis KW - ultrasound 2D KW - cerebellar vermis AB - Purpose: To provide 2-dimensional ultrasonographic (2D-US) normograms of cerebellar vermis biometry, as well as to evaluate the feasibility and the reproducibility of these measurements in clinical practice.Materials and Methods: A prospective cross-sectional study of 328 normal singleton pregnancies between 18 and 33 weeks of gestation. Measurements of the fetal cerebellar vermis circumference (VC) in the mid-sagittal plane were performed by both a senior and a junior operator using 2D-US. VC as a function of gestational age (GA) was expressed by regression equations. In 24 fetuses 3-dimensional (3D) reconstructed planes were obtained in order to allow comparisons with 2D-US measurements. The agreement between 2D and 3D measurements and the interobserver variability were assessed by interclass correlation coefficients (ICC).Results: Satisfactory vermis measurements could be obtained in 89.9% of cases. The VC (constant= − 12.21; slope=2.447; r=0.887, p<0.0001) correlated linearly with GA. A high degree of consistency was observed between 2D and 3D ultrasound measurements (ICC=0.846 95% CI 679–0.930) as well as between measurements obtained by different examiners (ICC=0.890 95% CI 989–0.945).Conclusion: 2-dimensional ultrasonographic measurements of cerebellar vermis throughout gestation in the mid-sagittal view seem to be feasible and reproducible enough to be potentially used in clinical practice. Such measurements may supply a tool for accurate identification of posterior fossa anomalies, providing the basis for proper counseling and management and of these conditions. PB - © Georg Thieme Verlag KG DO - 10.1055/s-0042-119952 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-119952 ER -