TY - JOUR AU - Abiodun, O. O.; Oshinloye, A. O. TI - Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis SN - 2194-9379 SN - 2194-9387 PY - 2017 JO - Drug Res (Stuttg) JF - Drug Research LA - EN VL - 67 IS - 01 SP - 20 EP - 24 ET - 2016/09/14 DA - 2017/01/17 KW - Carpolobia lutea KW - colitis KW - rats KW - glutathione KW - superoxide dismutase KW - myeloperoxidase KW - tumour necrotic factor alpha (TNF-α) AB - Carpolobia lutea G. Don (CL) is used in folk medicine for the treatment of inflammatory disorders. Effort in this study is to evaluate the beneficial effect of the aqueous-methanol extract of leaf of CL in a rat model of acetic acid induced colitis. Male Wistar rats were distributed into 6 groups of 7 rats each; non colitic, untreated colitic and colitic rats treated with graded doses of CL (100–800 mg/kg). Rats were pre-treated for 2 days before colitis induction and thereafter for 7 days post colitic induction. 24 h after the last treatment, animals were sacrificed and colonic inflammation was evaluated both macroscopically and biochemically. Macroscopic damage score, weight/length ratio, myeloperoxidase (MPO) activity and tumor necrotic factor alpha (TNF-α) levels, were significantly higher in untreated colitic rats in comparison with non colitic rats (P<0.05). Treatment with CL significantly reduced the macroscopic damage scores, neutrophil infiltration (MPO activity) and TNF-α level (P<0.05). In addition, C. lutea significantly prevented depletion of colonic GSH and (SOD) levels (P<0.05). It appears that the beneficial effect of methanol extract of C. lutea leaf observed in this study is dose dependent and is related to its antioxidant and anti-inflammatory activity. PB - © Georg Thieme Verlag KG DO - 10.1055/s-0042-114572 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-114572 ER -