TY - JOUR AU - Sun, Bin; Li, Deyu; Zhuang, Xiaohui; Zhu, Rui; Aisha, Aertuke; Jin, Can TI - Visible-Light-Triggered Decarboxylative Alkylation of 8-Acylaminoquinoline with N-Hydroxyphthalimide Ester SN - 0936-5214 SN - 1437-2096 PY - 2020 JO - Synlett JF - Synlett LA - EN VL - 31 IS - 07 SP - 677 EP - 682 ET - 2020/01/28 DA - 2020/03/25 KW - 8-aminoquinoline KW - visible light KW - C–H alkylation KW - decarboxylation AB - A facile protocol for visible-light-induced decarboxylative radical coupling of NHP esters with 8-aminoquinoline amides is reported, affording a highly efficient approach to synthesize a variety of 2-alkylated or 2,4-dialkylated 8-aminoquinoline derivatives. The reaction proceeds smoothly without adding any ligand, and provides the corresponding products containing a wide range of functional groups in moderate to excellent yields. This reaction uses readily available starting materials, and proceeds under mild conditions and with operational simplicity. PB - © Georg Thieme Verlag DO - 10.1055/s-0039-1691579 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1691579 ER -