TY - JOUR AU - Glazier, James J.; Kaki, Amir TI - The Impella Device: Historical Background, Clinical Applications and Future Directions SN - 1061-1711 SN - 1615-5939 PY - 2019 JO - Int J Angiol JF - International Journal of Angiology LA - EN VL - 28 IS - 02 SP - 118 EP - 123 ET - 2018/12/20 DA - 2019/08/04 KW - Impella device KW - mechanical circulatory support KW - ventricular assist device KW - cardiogenic shock KW - high risk coronary angioplasty KW - postcardiotomy shock KW - Archimedes' screw AB - The Impella device is a catheter-based miniaturized ventricular assist device. Using a retrograde femoral artery access, it is placed in the left ventricle across the aortic valve. The device pumps blood from left ventricle into ascending aorta and helps to maintain a systemic circulation at an upper rate between 2.5 and 5.0 L/min. This results in almost immediate and sustained unloading of the left ventricle, while increasing overall systemic cardiac output. The most common indications for using the Impella device are in the treatment of acute myocardial infarction complicated by cardiogenic shock and to facilitate high risk coronary angioplasty. Other indications include the treatment of cardiomyopathy with acute decompensation, postcardiotomy shock, and off-pump coronary bypass surgery. A growing body of observational and registry data suggest a potentially valuable role for the Impella system in reducing the mortality associated with cardiogenic shock. However, there are, as of yet, no randomized controlled trial data supporting this observation. PB - Thieme Medical Publishers DO - 10.1055/s-0038-1676369 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1676369 ER -