TY - JOUR AU - Nemeth, Banne; van Adrichem, Raymond A.; van Hylckama Vlieg, Astrid; Baglin, Trevor; Rosendaal, Frits R.; Nelissen, Rob G. H. H.; le Cessie, Saskia; Cannegieter, Suzanne C. TI - Venous Thrombosis Risk after Arthroscopy of the Knee: Derivation and Validation of the L-TRiP(ascopy) Score SN - 0340-6245 SN - 2567-689X PY - 2018 JO - Thromb Haemost JF - Thrombosis and Haemostasis LA - EN VL - 118 IS - 10 SP - 1823 EP - 1831 ET - 2018/09/20 DA - 2018/10/01 KW - venous thrombosis KW - risk factors KW - epidemiological studies KW - orthopaedics KW - prevention AB - Patients at high risk for venous thrombosis (VT) following knee arthroscopy could potentially benefit from thromboprophylaxis. We explored the predictive values of environmental, genetic risk factors and levels of coagulation markers to integrate these into a prediction model. Using a population-based case–control study into the aetiology of VT, we developed a Complete (all variables), Screening (easy to use in clinical practice) and Clinical (only environmental risk factors) model. The Clinical model was transformed into the Leiden-Thrombosis Risk Prediction (arthroscopy) score [L-TRiP(ascopy) score]. Model validation was performed both internally and externally in another case–control study. A total of 4,943 cases and 6,294 controls were maintained in the analyses, 107 cases and 26 controls had undergone knee arthroscopy. Twelve predictor variables (8 environmental, 3 haemorheological and 1 genetic) were selected from 52 candidates and incorporated into the Complete model (area under the curve [AUC] of 0.81, 95% confidence interval [CI], 0.76–0.86). The Screening model (9 predictors: environmental factors plus factor VIII activity) reached an AUC of 0.76 (95% CI, 0.64–0.88) and the Clinical (and corresponding L-TRiP(ascopy)) model an AUC of 0.72 (95% CI, 0.60–0.83). In the internal and external validation, the Complete model reached an AUC of 0.78 (95% CI, 0.52–0.98) and 0.75 (95% CI, 0.42–1.00), respectively, while the other models performed slightly less well. PB - Georg Thieme Verlag KG DO - 10.1055/s-0038-1670660 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1670660 ER -