TY - JOUR AU - Safi, Elem; Ficklscherer, Andreas; Bondarava, Maryna; Betz, Oliver; Zhang, Anja; Jansson, Volkmar; Müller, Peter E. TI - Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats SN - 2282-4324 SN - 2512-9090 PY - 2018 JO - Joints JF - Joints LA - EN VL - 06 IS - 01 SP - 004 EP - 009 ET - 2018/03/13 DA - 2018/04/18 KW - bursal tissue KW - rotator cuff KW - mesenchymal stem cells KW - cell migration KW - rats AB - Purpose The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats.Methods Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery.Results Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons.Conclusion Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons.Clinical Relevance Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff. PB - Georg Thieme Verlag KG DO - 10.1055/s-0038-1636948 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1636948 ER -