TY - JOUR AU - Box, Hayden N.; Shahrestani, Sean; Huo, Michael H. TI - Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty SN - 1538-8506 SN - 1938-2480 PY - 2018 JO - J Knee Surg JF - The Journal of Knee Surgery LA - EN VL - 31 IS - 07 SP - 605 EP - 609 ET - 2018/03/07 DA - 2018/07/17 KW - total knee arthroplasty KW - venous thromboembolism prophylaxis KW - total knee arthroplasty complications AB - Venous thromboembolic disease (VTED) is a major cause of morbidity and mortality after total knee arthroplasty (TKA). Current VTED prophylaxis protocols consist of early mobilization, mechanical compression devices, and pharmacologic agents. Venous phasic flow-regulated below-knee devices are generally favored, but the optimal duration and method of mechanical prophylaxis is unknown. Risk stratification models have been developed to guide pharmacologic prophylaxis. For patients with standard VTED risk profile, aspirin has become increasingly popular. Recent studies have validated the efficacy, relatively low bleeding risks, and cost-effectiveness of aspirin in the patients with standard risk profile. Current evidence suggests that the newer oral anticoagulants, including the factor Xa and the direct thrombin inhibitors, are effective for the reduction of postoperative VTED but may be associated with increased bleeding and wound complication rates. PB - Thieme Medical Publishers DO - 10.1055/s-0038-1636907 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1636907 ER -