Recombinant tissuetype plasminogen activator (Alteplase) for ischemic stroke3 to5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke - Clark, WM; Wissman, S; Albers, GW; Jhamandas, JH; Madden, KP; Hamilton, S (Jama, 1999)