TY - JOUR AU - Meller, B.; von Hof, K.; Genina, E.; Deisting, W.; Meller, J.; Richter, E.; Baehre, M. TI - Diagnostic 123I and 131I activities and radioiodine therapy T2 - Effects on urinary iodine excretion in patients with differentiated thyroid Carcinoma TT - Diagnostische 123I- und 131I-Aktivitäten sowie Radioiodtherapie SN - 0029-5566 SN - 2567-6407 PY - 2005 JO - Nuklearmedizin JF - Nuklearmedizin - NuclearMedicine LA - DE VL - 44 IS - 06 SP - 243 EP - 248 DA - 2018/01/11 KW - Thyroid carcinoma KW - radioiodine scintigraphy KW - radioiodine therapy KW - urinary iodine excretion AB - Aim: Urinary iodine excretion (UIE) provides information about iodine supply and release. In the present study we investigated effects of the application of different radioiodine isotopes on UIE in patients with differentiated thyroid carcinoma (DTC). Patients, methods: In 91 consecutive patients with DTC UIE, measured as iodine/creatinine ratio, was determined before and after application of 123I and 131I for diagnostic or therapeutic purposes. Additionally, remnant volume (V) was determined prior to therapy. Group A consisted of 33 patients with supposed successful ablation of DTC. These patients received 370 MBq 131I for diagnostic use and served as controls. 58 patients (group B) with remnants, relapses and metastases received 370 MBq 123I for diagnostics prior to therapy with 1.5-22.2 GBq 131I. Factors influencing individual changes in urinary iodine excretion (ΔUIE) were investigated by using non-parametric tests. Results: In group A UIE did not change significantly after application of 131I. As well, UIE remained unchanged after diagnostic application of 123I in group B. In contrast, UIE increased significantly already 24 h after therapeutic application of 131I in this group. In patients with small remnants (V < 2.5 ml) a significant but only moderate increase of UIE could be observed (average increase: 47 μg I/g crea). In patients with larger remnants, with relapses or metastases increase of UIE values was significant and more pronounced. Conclusions: It was confirmed that UIE increased significantly during radioiodine therapy in patients with DTC and radioiodine-accumulating tissue. The increase of UIE after therapeutic administration of radioiodine can be explained by the disintegrated thyroid follicles in thyroid remnants. The radioiodine-induced iodine release may be one reason for thyroid “stunning” even after application of diagnostic amounts of 131I. PB - Schattauer GmbH DO - 10.1055/s-0038-1625321 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1625321 ER -