TY - JOUR AU - Kim, Sonhwan; Lee, Won Koo; Ha, Hyun-Joon TI - Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxy­phenyl)dihydrofuran-2(3H)-one SN - 0039-7881 SN - 1437-210X PY - 2019 JO - Synthesis JF - Synthesis LA - EN VL - 51 IS - 04 SP - 885 EP - 888 ET - 2018/11/08 DA - 2019/02/01 KW - asymmetric synthesis KW - γ-aminomethyl-γ-lactone KW - aziridines KW - ring opening AB - The asymmetric synthesis of (3R,5S)-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one, as the most potent selective inactivator of monoamine B, was successfully achieved by applying a newly developed synthetic method toward the key γ-aminomethyl-γ-lactone via intramolecular aziridine ring opening in 63% overall yield from a commercial starting material. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1610667 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610667 ER -