TY - JOUR AU - Dalpozzo, Renato; Mancuso, Raffaella TI - Enantioselective Vinylogous Reactions of 3-Alkylidene Oxindoles SN - 0039-7881 SN - 1437-210X PY - 2018 JO - Synthesis JF - Synthesis LA - EN VL - 50 IS - 13 SP - 2463 EP - 2472 ET - 2018/05/30 DA - 2018/06/19 KW - oxindole KW - vinylogous reactions KW - asymmetric synthesis KW - organocatalysis KW - metal catalysis AB - Oxindoles represent an important class of bioactive compounds and synthetic derivatives found in many natural products. Most of these compounds are chiral molecules and the challenge of their asymmetric synthesis has fascinated many research groups. In particular, the creation of chiral centers out of the oxindole ring by vinylogous addition to 3-alkylidene-substituted oxindoles (3-alkylidene-1,3-dihydro-2H-indol-2-ones) has emerged in recent years. This review aims to give an overview of this topic.1 Introduction2 Aldol and Mannich Reactions3 Addition to Unsaturated Carbonyl Compounds4 Addition to Nitroalkenes5 Miscellaneous6 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1609731 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1609731 ER -