TY - JOUR AU - Silva, Eduarda M. P.; Rocha, Djenisa H. A.; Silva, Artur M. S. TI - Diels–Alder Reactions of 1,2-Dihydropyridines: An Efficient Tool for the Synthesis of Isoquinuclidines SN - 0039-7881 SN - 1437-210X PY - 2018 JO - Synthesis JF - Synthesis LA - EN VL - 50 IS - 09 SP - 1773 EP - 1782 ET - 2018/04/04 DA - 2018/04/18 KW - organocatalysis KW - organometallic catalysis KW - asymmetric transformations KW - enantioselective reactions KW - Lewis acids KW - alkaloids KW - ibogaine KW - Tamiflu AB - The Diels–Alder reaction of 1,2-dihydropyridines with different dienophiles is a well-established and straightforward method for the synthesis of isoquinuclidines. Nevertheless, the enantioselective preparation of isoquinuclidines using organocatalysts or organometallic catalysts is rather unexplored. This succinct review offers readers an overall perspective of the most important recent developments and concepts related to this topic.1 Introduction2 Asymmetric Diels–Alder Reaction of 1,2-Dihydropyridines2.1 Transition-Metal-Catalyzed Reactions2.2 Organocatalyzed Reactions3 Diels–Alder Reaction of 1,2-Dihydropyridines in the Synthesis of Biologically Valuable Compounds4 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1609418 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1609418 ER -