TY - JOUR AU - Kummari, Bhaskar; Ramesh, Perla; Polkam, Naveen; Malthum, Shankaraiah; Vishnuvardhan, M. V. P. S.; Anireddy, Jaya Shree TI - Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules SN - 2509-9396 PY - 2018 JO - SynOpen JF - SynOpen LA - EN VL - 02 IS - 01 SP - 0017 EP - 0024 DA - 2018/01/29 KW - synthesis KW - etodolac KW - oxadiozoles KW - triazoles KW - cytotoxicity AB - A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines. PB - Georg Thieme Verlag DO - 10.1055/s-0036-1591754 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1591754 ER -