TY - JOUR AU - Philipps, Arne R.; Blümel, Marcus; Dochain, Simon; Hack, Daniel; Enders, Dieter TI - Enantioselective Catalytic One-Pot Synthesis of Functionalized Methyleneindanes and Methylindenes via a Michael/Conia-Ene Sequence SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 07 SP - 1538 EP - 1546 ET - 2016/12/06 DA - 2017/03/16 KW - organocatalysis KW - indium catalysis KW - Conia-ene reaction KW - indanes KW - indenes AB - An enantioselective one-pot Michael addition/Conia-ene reaction sequence catalyzed by the combination of a squaramide and indium(III) triflate has been developed. Employing 2-ethynyl-β-nitrostyrenes and 1,3-dicarbonyl compounds as substrates, the functionalized methyleneindanes and methylindenes are obtained in good to excellent enantiomeric excesses. For the indane/indene conversion a concerted fragmentation is proposed. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588113 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588113 ER -