TY - JOUR AU - Joham, Anju E.; Palomba, Stefano; Hart, Roger TI - Polycystic Ovary Syndrome, Obesity, and Pregnancy SN - 1526-8004 SN - 1526-4564 PY - 2016 JO - Semin Reprod Med JF - Seminars in Reproductive Medicine LA - EN VL - 34 IS - 02 SP - 093 EP - 101 ET - 2016/02/08 DA - 2016/02/25 KW - PCOS KW - obesity KW - pregnancy complications AB - Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to one in five reproductive-aged women. It is underpinned by insulin resistance and hyperandrogenism and is associated with metabolic, reproductive, and psychological features. Women with PCOS have higher rates of obesity and central adiposity compared with women without PCOS, and weight strongly influences prevalence and clinical severity of PCOS. Women with PCOS may have subfertility and women should be aware of factors affecting fertility, in particular the impact of obesity and age. Once pregnant, women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes, hypertensive disorders, premature delivery, and delivery by cesarean section. The offspring of women with PCOS may have increased risk of congenital abnormalities and hospitalization in childhood. Clinicians should be aware of the increased risk and screen, prevent, and manage accordingly. PB - Thieme Medical Publishers DO - 10.1055/s-0035-1571195 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1571195 ER -