TY - JOUR AU - Schmid, Fabian; Baro, Angelika; Laschat, Sabine TI - Strategies for the Synthesis of Deoxypropionates SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 02 SP - 237 EP - 251 ET - 2016/09/09 DA - 2016/12/19 KW - deoxypropionates KW - polypropionates KW - polyketides KW - natural products KW - total synthesis KW - stereoselective synthesis AB - Deoxypropionates constitute an important class of polyketide natural products. The biological properties of deoxypropionates are diverse and synthetic strategies toward their preparation are equally manifold. This short review presents some recent developments on the synthesis of deoxypropionate units involving, besides iterative and non-iterative routes, other methods such as stereoselective Mukaiyama reactions or lithiation–borylation–protodeboronation sequences.1 Introduction2 Biosynthesis of Deoxypropionates3 Iterative Synthetic Methods3.1 Conjugate Addition of Cuprates3.2 Copper-Catalyzed Conjugate Additions3.3 Copper-Mediated Allylic Substitution3.4 Myers Alkylation3.5 Zirconium-Catalyzed Carboalumination3.6 Homologation of Boronates with Organolithiums4 Non-Iterative Methods4.1 Enzymatic Desymmetrization4.2 Ex Chiral Pool Synthesis from Wax Esters4.3 Ex Chiral Pool Synthesis from the Roche Ester4.4 Sequential [3,3]-Sigmatropic Rearrangement and Catalytic Hydrogenation5 Miscellaneous Methods6 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0035-1562540 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1562540 ER -