TY - JOUR AU - Zhang, Xiao-Yan; Hu, Li-Li; Shen, Ze; Chen, Zhong-Zhu; Xu, Zhi-Gang; Li, Shi-Qiang; Xie, Jian-Wu; Cui, Hai-Lei TI - Copper-Catalyzed Synthesis of Furo[3,2-c]coumarins and Dihydrofuro[3,2-c]coumarins through a Propargylation/Alkyne Oxacyclization/Isomerization Cascade under Microwave Irradiation SN - 0936-5214 SN - 1437-2096 PY - 2015 JO - Synlett JF - Synlett LA - EN VL - 26 IS - 20 SP - 2821 EP - 2825 ET - 2015/10/13 DA - 2015/12/07 KW - cascade reactions KW - coumarins KW - propargyl acetates KW - furocoumarins KW - cyclization AB - A novel copper-catalyzed microwave-promoted propargyl­ation/alkyne oxacyclization/isomerization cascade for the synthesis of 2-methylfuro[3,2-c]coumarins has been developed. This reaction provides furo[3,2-c]coumarins in moderate to good yields (≤82%) from readily available 4-hydroxycoumarins and terminal propargyl acetates as starting materials. Interestingly, by changing the solvent from dimethyl sulfoxide to 1,2-dichloroethane, the isomeric series of 2-meth­ylene-2,3-dihydrofuro[3,2-c]coumarins were obtained in good to acceptable yields (≤85%). PB - © Georg Thieme Verlag DO - 10.1055/s-0035-1560500 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1560500 ER -