TY - JOUR AU - Marquise, Nada; Nguyen, Tan Tai; Chevallier, Floris; Picot, Laurent; Thiéry, Valérie; Lozach, Olivier; Bach, Stéphane; Ruchaud, Sandrine; Mongin, Florence TI - Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines SN - 0936-5214 SN - 1437-2096 PY - 2015 JO - Synlett JF - Synlett LA - EN VL - 26 IS - 20 SP - 2811 EP - 2816 ET - 2015/09/30 DA - 2015/12/07 KW - diaryl ketone KW - pyrimidine KW - deprotometalation KW - mixed-metal amide KW - variolin analogue AB - The synthesis of triaryl methanols was investigated by reacting different 4-metalated 2-substituted pyrimidines with diaryl ketones, the latter being generated by deprotocupration–aroylation of azine and diazine substrates. Cyclization of the triaryl methanols thus obtained afforded pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines, which were evaluated for kinase inhibition and antiproliferative activities in melanoma cells. PB - © Georg Thieme Verlag DO - 10.1055/s-0035-1560496 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1560496 ER -