TY - JOUR AU - Torres, Susana Y.; Rebolledo, Francisca TI - A Highly Efficient Synthesis of Optically Active Hybrid 1H-1,5-Benzodiazepine–1,4-Dihydropyridines SN - 0039-7881 SN - 1437-210X PY - 2016 JO - Synthesis JF - Synthesis LA - EN VL - 48 IS - 09 SP - 1414 EP - 1420 ET - 2016/02/17 DA - 2016/04/19 KW - 1,5-benzodiazepine KW - 1,4-dihydropyridine KW - fused-ring systems KW - trifluoroacetic acid KW - chirality AB - A series of optically active hybrid compounds, 4-aryl-3-(ethoxycarbonyl)-2-methyl-4,11-dihydro-1H-benzo[b]pyrido[2,3-e][1,4]di­azepin-6-ium salts, containing the 1H-1,5-benzodiazepine and 1,4-dihydropyridine units have been effectively synthesized by means of a coupling reaction between enantioenriched 6-chloro-5-formyl-1,4-dihydropyridine derivatives and benzene-1,2-diamine. The use of trifluoroacetic acid allowed the corresponding hybrids to be obtained in very high yields. No racemization took place in the processes. PB - © Georg Thieme Verlag DO - 10.1055/s-0035-1560409 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1560409 ER -